Heres how to disable it from the CS4 iteration of their software offerings.
1. Go to HKEY_LOCAL_MACHINE\SOFTWARE\Adobe\
2. Set "AdobeOnlineDefault" to "0" (zero). If it
doesnt exist, create it as a new String Value.
3. Go to HKEY_LOCAL_MACHINE\SOFTWARE\Adobe\CSXSPreferences\
4. Set "UpdatesAllowed" to "0" (zero).
If it doesnt exist, create it as a new String Value.
or
REG ADD "HKEY_LOCAL_MACHINE\SOFTWARE\Adobe" /f /v AdobeOnlineDefault /d "0"
and
REG ADD "HKEY_LOCAL_MACHINE\SOFTWARE\Adobe\CSXSPreferences" /f /v UpdatesAllowed /d "0"
